- 17. 3. 2021
- IVF news
ASSISTED REPRODUCTION IS LIVING FIELD OF SCIENCE
WHEN IT COMES TO CLINICAL STUDIES IT IS FOR SURE LONG RUN PROCESS, BUT RESEARCH IS ONGOING AND NEW DEVELOPMENTS INTRODUCED.
These new discoveries might appear as insignificant, but all of these contributions from researchers result in knowledge being used to develop new treatments, technologies, and approaches to infertility.
Any piece of new information is the puzzle piece leading to an important findings. We stay up to date with the latest research in assisted reproduction field and apply proven findings into our procedures.
A GLOBAL FERTILITY DECLINE
Fertility declining trend is an alarming one. Global study, published in The Lancet, looked at fertility rates for last 70 years covering 195 countries around the world. And to say in general, people are having fewer children, and they are having them later in life.
How does this fertility decline affect the person thinking about own fertility? Considering the fact many women may not be planning to even try for a baby until their mid-thirties, it appears it becomes critical to be informed about the fertility facts and be pro-active about your fertility early on. Women's fertility tends to take a steep dive as their eggs age and when they are finally ready to conceive it is not happening. As making plans for the future, it is advised to know your fertility and options.
FERTILITY TESTS FOR YOUNGER WOMEN
Young women in their 20s and early 30s undergoes more and more often routine fertility testing even though they do not have any particular concerns about their fertility. Testing can be done at any stage of the woman's cycle and also if on hormonal birth control. An AMH blood test and ultrasound define ovarian reserve (the number of healthy eggs woman has). This fertility status can lead to making decisions about freezing eggs for later. This new trend for early fertility tests is a very empowering shift: instead of waiting until there is a problem, young women are thinking ahead and are making sure they have the information they need to make informed choices about their future.
Woman's age is one of the major limiting factors in fertility. Fertility preservation, so-called social freezing, is the one to be considered. Elective egg freezing is very wise choice to make when global fertility decline is the continuous trend and the age issues is one of the main factors of infertility. Thanks to general awareness spread and education on these fertility facts more women in their most reproductive age are choosing to freeze eggs and effectively stopping the clock on their fertility until they are ready to get pregnant. Fertility preservation offers more options and a chance to engage with your fertility on your terms.
NEW TECHNOLOGIES IN ASSISTED REPRODUCTION FILED
Technology is the very heart of assisted reproduction allowing us to offer couples advanced fertility treatments. It is exciting to discover new technologies in the field which leads to improving success rates.
DATA ANALYSIS is hugely important part of fertility. Newest technologies may have a lot to offer to all branches of medicine, including fertility medicine. With the help of smarter data analysis strategies, so-called "precision medicine" helps women suffering from repeated implantation failure. This is a particularly difficult situation, where patients undergoing IVF repeatedly fail to remain pregnant after the embryo transfer, even when all signs look positive and transfered embryos are the top quality.
THE ENDOMETRIAL RECEPTIVITY TEST (ERA test) is modern test which can help pinpoint unique optimal time for conception so transfer is scheduled on the day when the uterine lining is the most receptive. This leads into improving chances of getting and staying pregnant. The endometrial receptivity test looks at 238 genes in a sample of a woman's endometrial tissue. When the endometrial (uterine) lining is receptive to implantation, the genetic material of these endometrial cells shows a unique expression, based on the amount of RNA generated by these cells. Using an extensive database containing thousands samples of endometrial tissue, researchers were able to determine the levels of RNA produced at different times of a woman's cycle. Then, they applied advanced computer algorithms to the data set, searching for patterns which allow them to reliably classify a sample as "Receptive" or "Non-Receptive" according to its specific expression profiles.
Data analysis helps gaining a more complete picture of how patients might respond to certain treatments. Algorithms are being used in fertility treatment, for example with the EmbryoScope. Its software assists the embryologist select the most viable embryos for transfer.
SOPHISTICATED EMBRYO SCREENING
Genetic screening of embryos has become an important option for many patients undergoing IVF. Pre-implantation Genetic Testing has made it possible to screen embryos for a wide range of genetically transmissible diseases and choose the embryo for transfer which is not carrier of this information.
FURTHER FERTILITY RESEARCH
Some of the results and findings published in medical journals may still be years away from practical application to infertility treatments, but they give us all hope for the future. For example at the European Society of Human Reproduction and Embryology conference was introduced research about the potential to immediately improve the way IVF labs evaluate egg quality. Using a non-invasive polarised light technique to examine eggs in the lab during the ICSI procedure, the researchers discovered that the shape and profile of the oocytes (known as meiotic spindle morphology) could be used as a "predictive marker of fertilisation, blastocyst formation and the genetic normality of the resulting day five embryo." Meaning that there could be a relatively simple way to identify better the eggs most likely to develop into viable blastocysts once fertilised.