PGD/PGS REFERS TO A NUMBER OF SCREENING PROCEDURES PERFORMED BEFORE EMBRYOS ARE TRANSFERRED INTO THE UTERUS.
PGD/PGS ALLOW FOR THE EXCLUSION OF EMBRYOS WITH GENETIC DISORDERS, INCLUDING CHROMOSOMAL ABNORMALITIES SUCH AS CHROMOSOMAL TRANSLOCATION, ANEUPLOIDY OR OTHER STRUCTURAL DEFECTS, OR MONOGENIC DISORDERS.
A cell (blastomere) of the embryo is extracted and subjected to comprehensive genetic analysis.
PRE-IMPLANTATION GENETIC DIAGNOSIS – PGD
The preimplantation genetic diagnosis of translocations (or other structural chromosomal disorders) is suitable for couples where one or both partners are proven to be carriers of a balanced translocation or other structural chromosomal alteration. Today, you can investigate most translocations using NGS (Next Generation Sequencing) methods or by using Karyomapping. PGD screens embryos created through IVF for inheritable serious genetic disorders in order to avoid passing on the condition to offspring.
PRE-IMPLANTATION GENETIC SCREENING – PGS
The pre-implatation genetic screening allows the choice of a perspective embryo with a normal number of chromosomes for transfer to the uterus. Such an embryo then has the greatest chance to be implanted and will not be miscarried and will lead to the birth of a healthy child.PGS is a screening process that helps identify chromosomal abnormalities e.g. Downs Syndrome before the embryo is implanted in the uterus.
REASONS FOR PGD / PGS
- Compromised embryo development in previous cycles
- Spermogram results repeatedly at the low end of the norm
- History of miscarriage
- History of genetic disorders
- Advanced age of man or woman